Safety Sheet Methylene Blue

SAFETY DATA SHEET *

according to Regulation (EC) No. 453/2010
Version 5.2 Revision Date 11.08.2015
Print Date 09.02.2016
GENERIC EU MSDS – NO COUNTRY SPECIFIC DATA – NO OEL DATA

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifiers

Product name : Methylene blue
Product Number : M9140
Brand : Sigma-Aldrich
REACH No. : A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
CAS-No. : 7220-79-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Chemie GmbH
Riedstrasse 2
D-89555 STEINHEIM
Telephone : +49 89-6513-1444
Fax : +49 7329-97-2319
E-mail address : [email protected]

1.4 Emergency telephone number

Emergency Phone # : +49 7329-97-2323

SECTION 2: HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling according Regulation (EC) No 1272/2008
Pictogram:                         

Signal word:                    Warning

Hazard statement(s):
H302 Harmful if swallowed.

Precautionary statement(s):
P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. Rinse mouth.

Supplemental Hazard Statements: none

2.3 Other hazards

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Synonyms : Tetramethylthionine chloride
3,7-bis(Dimethylamino)phenazathionium chloride
Basic Blue 9
Formula : C16H18ClN3S · 3H2O
Molecular Weight : 373,90 g/mol
CAS-No. : 7220-79-3
EC-No. : 200-515-2

Hazardous ingredients according to Regulation (EC) No 1272/2008
Component                                                              Classification                                                              Concentration
Methylthioninium chloride
CAS-No.                              7220-79-3                    Acute Tox. 4; H302                                                     <= 100 %
EC-No.                                 200-515-2

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: FIRST AID MEASURES

4.1 Description of first aid measures

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact
Wash off with soap and plenty of water.

In case of eye contact
Flush eyes with water as a precaution.

If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11

4.3 Indication of any immediate medical attention and special treatment needed

no data available

SECTION 5: FIREFIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas

5.3 Advice for firefighters

Wear self-contained breathing apparatus for fire fighting if necessary.

5.4 Further information

no data available

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: HANDLING AND STORAGE

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Storage class (TRGS 510): Non Combustible Solids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Components with workplace control parameters

8.2 Exposure controls

Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected],
test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure
Do not let product enter drains.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

a) Appearance: Form: powder, Colour: dark green
b) Odour: no data available
c) Odour Threshold no data available
d) pH: no data available
e) Melting point/freezing point: Melting point/range: 190 °C
f) Initial boiling point and boiling range: no data available
g) Flash point: no data available
h) Evaporation rate: no data available
i) Flammability (solid, gas): no data available
j) Upper/lower flammability or explosive limits: no data available
k) Vapour pressure no data available
l) Vapour density: no data available
m) Relative density: no data available
n) Water solubility: soluble
o) Partition coefficient: noctanol/water: no data available
p) Auto-ignition temperature: no data available
q) Decomposition temperature: no data available
r) Viscosity: no data available
s) Explosive properties: no data available
t) Oxidizing properties: no data available

9.2 Other safety information

no data available

SECTION 10: STABILITY AND REACTIVITY

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Other decomposition products – no data available

In the event of fire: see section 5

SECTION 11: TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

Acute toxicity
Harmful if swallowed
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity – single exposure
no data available
Specific target organ toxicity – repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: SP5740000
Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., Vomiting, Diarrhoea, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: ECOLOGICAL INFORMATION

12.1 Toxicity

no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects

no data available

SECTION 13: DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: TRANSPORT INFORMATION

14.1 UN number

ADR/RID: – IMDG: – IATA: –

14.2 UN proper shipping name

ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods

14.3 Transport hazard class(es)

ADR/RID: – IMDG: – IATA: –

14.4 Packaging group

ADR/RID: – IMDG: – IATA: –

14.5 Environmental hazards

ADR/RID: no IMDG Marine Pollutant: no IATA: no

14.6 Special precautions for user

no data available

SECTION 15: REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

 

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3.

H302 Harmful if swallowed.

Further information

Copyright 2015 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigmaaldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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